NEXome Mini Panel v1.0

Catalog Number:

#1001881
#1001882

NEXome Mini Panel focuses on the exome associated with clinical inherited diseases, with probe coverage spanning a 16.1 Mb genomic region involving 5650 clinically significant genes and encompassing over 4000 genetic disorders. In comparison to the whole exome panel, the NEXome Mini Panel can be used to rapidly and efficiently detect pathogenic genetic variations within target genes in the human genome. This not only reduces sequencing costs but also significantly shortens data analysis time.

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Feature

Highly Targeted: Focuses on the exome associated with clinical inherited diseases, covering a 16.1 Mb genomic region, involving 5650 genes related to over 4000 clinical genetic disorders.

High Accuracy: Based on the probe hybridization capture principle, it can accurately detect genetic variations within target genes, providing reliable data support for subsequent research.

High Efficiency: Compared to the whole exome Panel, the NEXome Mini Panel can rapidly detect pathogenic genetic variations within target genes, thereby reducing data analysis time and minimizing turnaround time.

Cost-effective: Aim to only include clinically significant regions specifically related to inherited diseases, effectively reducing sequencing costs.

Capture Performance

Figure 1. Capture performance of NEXome mini Panel v1.0. Cell Line gDNA Standard (Coriell, NA12878) were used to prepare library with the NadPrep DNA Library Preparation Kit (for Illumina®). NEXome Mini Panel v1.0 were used to complete hybridization capture. The BWA was used for alignment of raw reads to the reference genome (hg38). A. Mappability, On-target rate, and target coverage; B. GC Bias.

Note: Sequencing platform: Illumina Novaseq 6000，PE150.

High Confidence Variant Calls

Figure 2. Sensitivity and positive predictive value (PPV) of NEXome Mini Panel for NA12878 mutation identification.

More Efficient and Cost-effective

Figure 3. The NEXome Mini Panel reduces sequencing raw data to minimize costs. A. Minimum amount of raw data required for the NEXome Mini Panel and NEXome Core Panel to achieve a specific depth; B. Coverage region and relationship between the NEXome Mini Panel and NEXome Core Panel.

Catalog#	Color of Tube Cap	Product	Volume	Package/Storage
1001881		NEXome Mini Panel v1.0, 96 rxn	415 μL	-25 ~ -15℃
1001882		NEXome MIni Panel v1.0, 16 rxn	70 μL	-25 ~ -15℃